Basic Molecular Information

Basic Information

DICL ID
DICL_CP_0316539
PubChem CID
Molecular Formula
C14H18N4
Molecular Weight
242.326 g/mol
Synonyms/Alias
[CHEMBL4796860; BDBM50553737]
InChI Key
GFWITVCRRGEWNL-UHFFFAOYSA-N
InChI
InChI=1S/C14H18N4/c1-2-10(1)6-15-14-5-13-12(7-16-14)17-9-18(13)8-11-3-4-11/h5,7,9-11H,1-4,6,8H2,(H,1...
IUPAC Name
N,1-bis(cyclopropylmethyl)imidazo[4,5-c]pyridin-6-amine
CAS Number
N/A (Not available)

Structure Information

Chemical Structure Visualization

SMILES Notation
2D Molecular Drawing
Carbon (C)
Hydrogen (H)
Oxygen (O)
Nitrogen (N)
Sulfur (S)
SDF

36 39 0 0 0 0 0 0 0 0999 V2000
4.3464 -0.3004 1.3222 C 0 0 0 0 0 0 0 0 0 0 0 0
5.4375 0.5792 0.7352 C 0 0 0 0 0 0 0 0 0 0 0 0
3.9803 0.841...

Experimental Data

Activity Data

Target Ion Channel
Gamma-aminobutyric acid receptor subunit alpha-5/beta-3/gamma-2
Uniprot Accession Number
Function
Allosteric Modulator
Species
Rattus norvegicus (Rat)
IC50
N/A (Not available)
EC50
N/A (Not available)
Ki
Ki: >15000 nM
Kd
N/A (Not available)
Inhibition
N/A (Not available)

Experimental Conditions

pH
Not mention
Holding Potential
Not specified
Temperature
Not mention
Test Method
Binding assay ([3H] Ro15-1788)
Test Species
Not specified

Binding Information

Binding Site
Extracellular domain
Binding Site Residue
Benzodiazepine binding site

Disease Information

Related Disease
treatment of cognitive disorders

References

URL
N/A (Not available)
PMID
Patent
N/A (Not available)

Computed Properties

Heavy Atom Count
18
Rotatable Bonds
5
logP
2.6632
Complexity
71.4657
TPSA (Ų)
42.74
H-Bond Donors
1
H-Bond Acceptors
4
Ring Count
4
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